Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | CTSV | O60911 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6453692 | 0.88 | SMN1; SMN2 (0.52) | SMPD1HDAC1HDAC8HDAC6NPC1 | |
| SCHEMBL159448 | 0.85 | HTT (0.55) | SMPD1HDAC1HDAC8HDAC6NPC1 | |
| SCHEMBL874091 | 0.85 | HTT (0.55) | SMPD1HDAC1HDAC8HDAC6NPC1 | |
| SCHEMBL1656948 | 0.84 | SMPD1 (0.53) | SMPD1HDAC1HDAC8HDAC6NPC1 | |
| SCHEMBL19983333 | 0.82 | SMPD1 (0.54) | SMPD1HDAC1HDAC8HDAC6NPC1 | |
| SCHEMBL8039259 | 0.81 | LMNA (0.51) | SMPD1HDAC1HDAC8HDAC6NPC1 | |
| SCHEMBL160400 | 0.80 | MEN1 (0.57) | SMPD1HDAC1HDAC8HDAC6LMNA | |
| SCHEMBL873729 | 0.80 | MEN1 (0.57) | SMPD1HDAC1HDAC8HDAC6LMNA | |
| SCHEMBL3138320 | 0.78 | CTSV (0.57) | SMPD1HDAC1HDAC8HDAC6NPC1 | |
| SCHEMBL4728946 | 0.78 | CTSV (0.57) | SMPD1HDAC1HDAC8HDAC6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474420-A1 | QUINAZOLINE COMPOUNDS | Astrazeneca AB (SE) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003064413-A1 | QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-07 | — | — | WO | disclosed |