Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.78 |
| ▸ | NPC1 | O15118 | 2/20 | 0.78 |
| ▸ | RAB9A | P51151 | 2/20 | 0.78 |
| ▸ | HPGD | P15428 | 1/20 | 0.78 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.62 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | RXRA | P19793 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6811211 | 0.88 | SMN1; SMN2 (1.00) | SMN1; SMN2NPC1RAB9AHPGDMRGPRX4 | |
| SCHEMBL7047105 | 0.88 | SMN1; SMN2 (0.80) | SMN1; SMN2NPC1RAB9AHPGDMRGPRX4 | |
| SCHEMBL31194744 | 0.86 | NPC1 (0.78) | SMN1; SMN2NPC1RAB9AHPGDMRGPRX4 | |
| SCHEMBL1119481 | 0.86 | NPC1 (0.78) | SMN1; SMN2NPC1RAB9AHPGDMRGPRX4 | |
| SCHEMBL341249 | 0.86 | SMN1; SMN2 (0.78) | SMN1; SMN2NPC1RAB9AHPGDMRGPRX4 | |
| SCHEMBL6246974 | 0.86 | SMN1; SMN2 (0.78) | SMN1; SMN2NPC1RAB9AHPGDMRGPRX4 | |
| SCHEMBL27881765 | 0.86 | NPC1 (0.77) | SMN1; SMN2NPC1RAB9AHPGDMRGPRX4 | |
| SCHEMBL242563 | 0.86 | MRGPRX4 (0.77) | SMN1; SMN2NPC1RAB9AHPGDMRGPRX4 | |
| SCHEMBL4872484 | 0.85 | SMN1; SMN2 (0.76) | SMN1; SMN2NPC1RAB9AHPGDMRGPRX4 | |
| SCHEMBL340620 | 0.85 | NPC1 (0.75) | SMN1; SMN2NPC1RAB9AHPGDMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888310-B1 | CINNOLINE DERIVATIVES AND USE AS MEDICINE | ASTRAZENECA AB (SE) | 2005-09-07 | — | — | EP | disclosed |