Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | UGCG | Q16739 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6466882 | 0.95 | KDM4E (0.47) | PDE10AKDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6466886 | 0.95 | KDM4E (0.47) | PDE10AKDM4ELMNASMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6458051 | 0.95 | KDM4E (0.46) | PDE10AKDM4ELMNASMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6458059 | 0.95 | KDM4E (0.46) | PDE10AKDM4ELMNASMN1; SMN2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL6461567 | 0.93 | CNR1 (0.46) | PDE10AKDM4ELMNASMN1; SMN2PDE4B | |
| SCHEMBL6463804 | 0.90 | KDM4E (0.51) | PDE10AKDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6463808 | 0.90 | KDM4E (0.51) | PDE10AKDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6455213 | 0.89 | CNR1 (0.49) | PDE10AKDM4ELMNASMN1; SMN2PDE4B | |
| SCHEMBL6455217 | 0.89 | CNR1 (0.49) | PDE10AKDM4ELMNASMN1; SMN2PDE4B | |
| SCHEMBL6461557 | 0.89 | L3MBTL1 (0.51) | PDE10AKDM4ELMNASMN1; SMN2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | PDE10A 1335/4885KDM4E 1190/4885LMNA 3391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.