Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 2/20 | 0.50 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.49 |
| ▸ | CDK7 | P50613 | 5/20 | 0.48 |
| ▸ | CDK9 | P50750 | 4/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6463619 | 1.00 | PAK4 (0.50) | PAK4PAK1HRH4CDK7CDK9 | |
| Hydrochloric Acid SCHEMBL6464145 | 0.99 | PAK4 (0.49) | PAK4PAK1HRH4CDK7CDK9 | |
| SCHEMBL6461912 | 0.85 | JAK3 (0.41) | HRH4CDK1CCNB1MAPK8MAPK9 | |
| SCHEMBL6458459 | 0.85 | MAPK6 (0.42) | PAK4PAK1HRH4MAPK8MAPK9 | |
| SCHEMBL6464494 | 0.84 | CTSK (0.41) | HRH4CDK1CCNB1JAK3CDK2 | |
| Hydrochloric Acid SCHEMBL6463534 | 0.83 | MAPK6 (0.41) | PAK4PAK1HRH4MAPK8MAPK9 | |
| SCHEMBL6455641 | 0.82 | MCHR1 (0.48) | MAPK8MAPK9MAPK10AURKBJAK3 | |
| Hydrochloric Acid SCHEMBL6463526 | 0.81 | MAPK6 (0.43) | MAPK8JAK3LCKIRAK4MAPK14 | |
| Hydrochloric Acid SCHEMBL6463532 | 0.81 | MAPK6 (0.43) | MAPK8JAK3LCKIRAK4MAPK14 | |
| SCHEMBL13779899 | 0.81 | IKBKB (0.57) | HRH4CDK1CCNB1MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | PAK4 834/4885PAK1 1665/4885HRH4 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.