Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | AGTR1 | P30556 | 8/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | PPARG | P37231 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7043121 | 0.89 | AGTR1 (0.49) | CYP2C9AGTR1AGTR2ALDH1A1KDM4E | |
| SCHEMBL6449013 | 0.85 | KDM4E (0.63) | CYP2C9CYP1A2CYP2C19AGTR1AGTR2 | |
| SCHEMBL6450132 | 0.82 | KDM4E (0.40) | AGTR1AGTR2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6448038 | 0.81 | AGTR1 (0.50) | CYP2C9AGTR1AGTR2ALDH1A1KDM4E | |
| SCHEMBL9139364 | 0.79 | PPARG (0.66) | CYP2C9CYP1A2CYP2C19AGTR1AGTR2 | |
| SCHEMBL6451041 | 0.78 | AGTR1 (0.46) | CYP2C9AGTR1AGTR2ALDH1A1KDM4E | |
| SCHEMBL9137178 | 0.78 | PPARG (0.65) | CYP2C9CYP1A2CYP2C19AGTR1AGTR2 | |
| SCHEMBL6453074 | 0.77 | AGTR1 (0.43) | CYP2C9AGTR1AGTR2ALDH1A1KDM4E | |
| SCHEMBL12362496 | 0.76 | PPARG (0.45) | CYP2C9AGTR1AGTR2ALDH1A1KDM4E | |
| SCHEMBL8875125 | 0.76 | AGTR1 (0.54) | CYP2C9AGTR1AGTR2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050020654-A1 | Novel PPAR agonists, pharmaceutical compositions and uses thereof | BETHESDA PHARMACEUTICALS, INC. | 2005-01-27 | — | — | US | disclosed |
| WO-2004082621-A2 | NOVEL PPAR AGONISTS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BETHESDA PHARMACEUTICALS, INC. (US) | 2004-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020654-A1 | Novel PPAR agonists, pharmaceutical compositions and uses thereof | PPARG, PPARD, PPARA | CYP2C9 498/4885CYP1A2 317/4885CYP2C19 326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.