Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 4/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91812 | 1.00 | GRIA1 (0.42) | GRIA1GRIA2GRIA3KCNH2HRH3 | |
| SCHEMBL6459328 | 1.00 | GRIA1 (0.42) | GRIA1GRIA2GRIA3KCNH2HRH3 | |
| SCHEMBL6459320 | 1.00 | GRIA1 (0.42) | GRIA1GRIA2GRIA3KCNH2HRH3 | |
| SCHEMBL6459324 | 1.00 | GRIA1 (0.42) | GRIA1GRIA2GRIA3KCNH2HRH3 | |
| SCHEMBL8044943 | 0.95 | GRIA1 (0.40) | GRIA1GRIA2GRIA3KCNH2HRH3 | |
| SCHEMBL8044940 | 0.95 | GRIA1 (0.40) | GRIA1GRIA2GRIA3KCNH2HRH3 | |
| SCHEMBL9168960 | 0.95 | HRH3 (0.45) | GRIA1GRIA2GRIA3KCNH2HRH3 | |
| SCHEMBL8044951 | 0.95 | GRIA1 (0.40) | GRIA1GRIA2GRIA3KCNH2HRH3 | |
| SCHEMBL8044947 | 0.95 | GRIA1 (0.40) | GRIA1GRIA2GRIA3KCNH2HRH3 | |
| SCHEMBL9168952 | 0.95 | HRH3 (0.45) | GRIA1GRIA2GRIA3KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4676604-A | RADIATION RESISTANCE; MISCIBILITY; ROTATION ELECTROPTICAL CELLS | HOFFMANN-LA ROCHE INC. (US) | 1987-06-30 | — | — | US | claimed |
| US-6913797-B1 | Decahydronaphthalene derivative | DAINIPPON INK AND CHEMICALS, INC. (JP) | 2005-07-05 | — | — | US | disclosed |
| EP-1108700-A1 | DECAHYDRONAPHTHALENE DERIVATIVE | DAINIPPON INK AND CHEMICALS, INC. (JP) | 2001-06-20 | — | — | EP | disclosed |
| EP-0497176-B1 | Four rings compounds and liquid crystal mixtures containing them | MERCK PATENT GMBH (DE) | 2000-04-05 | — | — | EP | disclosed |
| US-5518653-A | LIQUID CRYSTAL | HOFFMANN-LA ROCHE INC. (US) | 1996-05-21 | — | — | US | disclosed |
| EP-0464648-B1 | 4-Cyano-3-fluorophenyl esters | HOFFMANN LA ROCHE (CH) | 1995-12-06 | — | — | EP | disclosed |
| US-5454974-A | Halobenzene liquid crystals | HOFFMANN-LA ROCHE INC. (US) | 1995-10-03 | — | — | US | disclosed |
| EP-0457105-B1 | Chiral dioxanes as components of liquid crystal mixtures | HOFFMANN LA ROCHE (CH) | 1995-07-26 | — | — | EP | disclosed |
| US-5413734-A | 4-cyano-3-fluorophenyl esters | HOFFMANN-LA ROCHE INC. (US) | 1995-05-09 | — | — | US | disclosed |
| US-5302317-A | Halobenzene liquid crystals | HOFFMANN-LA ROCHE INC. (US) | 1994-04-12 | — | — | US | disclosed |
| US-4915480-A | Liquid crystalline compounds and mixtures | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-04-10 | — | — | US | disclosed |
| EP-0355552-A2 | Alkoxymethyl- and alkenyloxymethyl-cyclohexanes | F. HOFFMANN-LA ROCHE AG (CH) | 1990-02-28 | — | — | EP | disclosed |
| EP-0331933-A2 | Liquid crystal mixture with a low optical anisotropy | F. HOFFMANN-LA ROCHE AG (CH) | 1989-09-13 | — | — | EP | disclosed |
| EP-0315014-A2 | Halogenated benzene derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-05-10 | — | — | EP | disclosed |
| EP-0169327-B1 | PHENYLISOTHIOCYANATES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1988-01-13 | — | — | EP | disclosed |
| EP-0122389-B1 | LIQUID CRYSTAL COMPONENTS HAVING AN ALKENYL CHAIN | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1987-08-05 | — | — | EP | disclosed |
| US-4676604-A | RADIATION RESISTANCE; MISCIBILITY; ROTATION ELECTROPTICAL CELLS | HOFFMANN-LA ROCHE INC. (US) | 1987-06-30 | — | — | US | disclosed |
| EP-0169327-A2 | Phenylisothiocyanates | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1986-01-29 | — | — | EP | disclosed |
| US-4565425-A | Liquid crystals | HOFFMANN-LA ROCHE INC. (US) | 1986-01-21 | — | — | US | disclosed |
| EP-0122389-A2 | Liquid crystal components having an alkenyl chain | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-10-24 | — | — | EP | disclosed |