Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GALR2 | O43603 | 2/20 | 0.36 |
| ▸ | GALR1 | P47211 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6459529 | 0.83 | NPC1 (0.51) | MCHR1ADRA2AMAPTNPC1RAB9A | |
| SCHEMBL4257938 | 0.82 | MCHR1 (0.42) | MCHR1MAPTPOLBGALR2GALR1 | |
| Trifluoroacetic Acid SCHEMBL6873701 | 0.77 | MCHR1 (0.46) | MCHR1ADRA2A | |
| SCHEMBL6461348 | 0.74 | MCHR1 (0.72) | MCHR1ADRA2A | |
| SCHEMBL6461358 | 0.74 | MCHR1 (0.72) | MCHR1ADRA2A | |
| SCHEMBL6455920 | 0.71 | MCHR1 (0.54) | MCHR1ADRA2A | |
| SCHEMBL6459651 | 0.70 | MCHR1 (0.67) | MCHR1ADRA2A | |
| SCHEMBL6462208 | 0.70 | MCHR1 (0.50) | MCHR1ADRA2ACDK1 | |
| Trifluoroacetic Acid SCHEMBL6455722 | 0.70 | MCHR1 (0.48) | MCHR1ADRA2AFLT3TYRO3MERTK | |
| SCHEMBL6459661 | 0.70 | MCHR1 (0.67) | MCHR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | MCHR1 2/4885ADRA2A 117/4885CDK1 594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.