Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6828256 | 0.84 | MCHR1 (0.56) | MCHR1ADRA2AHTR1A | |
| Trifluoroacetic Acid SCHEMBL6455911 | 0.84 | MCHR1 (0.56) | MCHR1ADRA2AHTR1A | |
| SCHEMBL6459533 | 0.83 | MCHR1 (0.44) | NPC1RAB9AMCHR1MAPTKMT2A | |
| SCHEMBL4037165 | 0.82 | MCHR1 (0.69) | NPC1RAB9AMCHR1MAPTKMT2A | |
| SCHEMBL4037177 | 0.82 | MCHR1 (0.69) | NPC1RAB9AMCHR1MAPTKMT2A | |
| Trifluoroacetic Acid SCHEMBL6873701 | 0.81 | MCHR1 (0.46) | MCHR1ADRA2AHTR1ACNR1KCNH2 | |
| SCHEMBL6460884 | 0.81 | MCHR1 (0.60) | NPC1RAB9AMCHR1MAPTKMT2A | |
| SCHEMBL6460896 | 0.81 | MCHR1 (0.60) | NPC1RAB9AMCHR1MAPTKMT2A | |
| Trifluoroacetic Acid SCHEMBL4257937 | 0.81 | NPC1 (0.52) | NPC1RAB9AMCHR1MAPTKMT2A | |
| SCHEMBL6464865 | 0.81 | MCHR1 (0.55) | NPC1MCHR1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | NPC1 778/4885RAB9A 1648/4885MCHR1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.