SCHEMBL6460025

SCHEMBL6460025

CNC(=O)/C(=N/OC)c1ccccc1COc1cccc(C(F)(F)F)c1

nearest known ligand 0.67

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 8/20 0.67
MCL1 Q07820 1/20 0.48
MRGPRX4 Q96LA9 2/20 0.43
KDM4E B2RXH2 2/20 0.43
MAOB P27338 1/20 0.43
IGF1R P08069 1/20 0.42
MET P08581 1/20 0.42
SRC P12931 1/20 0.42
ALDH1A1 P00352 1/20 0.41
MAPT P10636 1/20 0.41
HTT P42858 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8371507 1.00 HIF1A (0.67) HIF1AMCL1MRGPRX4KDM4EMAOB
SCHEMBL6460031 1.00 HIF1A (0.67) HIF1AMCL1MRGPRX4KDM4EMAOB
SCHEMBL8620470 0.90 HIF1A (0.55) HIF1AMCL1MRGPRX4KDM4EMAOB
SCHEMBL8620469 0.90 HIF1A (0.55) HIF1AMCL1MRGPRX4KDM4EMAOB
SCHEMBL8396210 0.90 HIF1A (0.65) HIF1AMCL1MRGPRX4KDM4EMAOB
SCHEMBL8396217 0.90 HIF1A (0.65) HIF1AMCL1MRGPRX4KDM4EMAOB
SCHEMBL8617320 0.90 HIF1A (0.66) HIF1AMCL1MRGPRX4KDM4EMAOB
SCHEMBL8617317 0.90 HIF1A (0.66) HIF1AMCL1MRGPRX4KDM4EMAOB
SCHEMBL8369843 0.89 HIF1A (0.59) HIF1AMRGPRX4MAOB
SCHEMBL8618334 0.89 HIF1A (0.67) HIF1AMCL1MRGPRX4KDM4EMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030055096-A1 Fungicidal composition OGURI YUKIO (JP) 2003-03-20 US claimed
EP-0741970-A1 BACTERICIDAL COMPOSITION SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1996-11-13 EP claimed
US-6838482-B2 Fungicidal composition SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-01-04 US disclosed
US-20030055096-A1 Fungicidal composition OGURI YUKIO (JP) 2003-03-20 US disclosed
EP-0644183-B1 Process of producing N-alkylacetamides SHIONOGI & CO (JP) 1999-06-02 EP disclosed
EP-0658541-B1 PROCESS FOR PRODUCING CARBOXYLIC ACID DERIVATIVE SHIONOGI & CO (JP) 1998-05-20 EP disclosed
EP-0741970-A1 BACTERICIDAL COMPOSITION SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1996-11-13 EP disclosed
EP-0737421-A1 BACTERICIDAL COMPOSITION SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1996-10-16 EP disclosed
US-5510506-A Process for producing carboxylic acid derivatives SHIONOGI & CO., LTD. (JP) 1996-04-23 US disclosed
US-5498792-A Process of producing N-alkylacetamides SHIONOGI & CO., LTD. (JP) 1996-03-12 US disclosed
EP-0658541-A1 PROCESS FOR PRODUCING CARBOXYLIC ACID DERIVATIVE SHIONOGI & CO., LTD. (JP) 1995-06-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030055096-A1 Fungicidal composition CBR1, CBR3, CYP1B1 HIF1A 2640/4885MCL1 2149/4885MRGPRX4 1359/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.