Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4013203 | 0.87 | TSHR (0.40) | ALDH1A1LMNAPKMRAB9AHSD17B10 | |
| SCHEMBL4013197 | 0.84 | MAP4K1 (0.43) | ALDH1A1MAP4K1HSD17B10SMN1; SMN2MAPK14 | |
| SCHEMBL4014853 | 0.82 | TSHR (0.36) | ALDH1A1LMNAPKMRAB9AHSD17B10 | |
| SCHEMBL6455968 | 0.77 | LRRK2 (0.38) | ALDH1A1LMNAPKMLRRK2MAP4K1 | |
| SCHEMBL4015109 | 0.71 | GPR6 (0.39) | LMNAPKMRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4013944 | 0.69 | MAP4K1 (0.46) | ALDH1A1LMNAMAP4K1HSD17B10LPAR2 | |
| SCHEMBL4017691 | 0.69 | NPC1 (0.41) | ALDH1A1MAP4K1RAB9AHSD17B10SMN1; SMN2 | |
| SCHEMBL4013244 | 0.66 | TSHR (0.47) | ALDH1A1RAB9AHSD17B10SMN1; SMN2MAPK14 | |
| SCHEMBL4017937 | 0.64 | L3MBTL1 (0.46) | ALDH1A1LMNAPKMRAB9ASMN1; SMN2 | |
| SCHEMBL8182920 | 0.61 | MAPK14 (0.56) | LMNAPKMRAB9AHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050203091-A1 | Heteroaryl-fused pyrazolo derivatives and methods for using the same | ROCHE PALO ALTO LLC | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203091-A1 | Heteroaryl-fused pyrazolo derivatives and methods for using the same | MAP3K1, MAP3K21, MAP3K2 | ALDH1A1 2726/4885LMNA 2771/4885PKM 486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.