Sugi Predict

Sugi Predict / Compounds / SCHEMBL6460675

SCHEMBL6460675

SCHEMBL6460675

CCCC1CC[C@@H]2C[C@H](c3ccc(-c4ccc(C5=NC(C)(C)CO5)c(F)c4)c(F)c3)CC[C@@H]2C1

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.35
▸ MAPT P10636 1/20 0.35
▸ HTT P42858 1/20 0.35
▸ FASN P49327 1/20 0.31
▸ IL2 P60568 1/20 0.31
▸ CYP2D6 P10635 1/20 0.31
▸ HRH3 Q9Y5N1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6460677 1.00 LMNA (0.35) LMNAMAPTHTTFASNIL2
SCHEMBL6455501 0.95 LMNA (0.34) LMNAMAPTHTTFASNIL2
SCHEMBL6455506 0.95 LMNA (0.34) LMNAMAPTHTTFASNIL2
SCHEMBL6459909 0.94 LMNA (0.33) LMNAMAPTHTTFASN
SCHEMBL6459915 0.94 LMNA (0.33) LMNAMAPTHTTFASN
SCHEMBL6457684 0.94 LMNA (0.37) LMNAMAPTHTTFASNIL2
SCHEMBL6457687 0.94 LMNA (0.37) LMNAMAPTHTTFASNIL2
SCHEMBL6454255 0.94 LMNA (0.35) LMNAMAPTHTTIL2CYP2D6
SCHEMBL6454249 0.94 LMNA (0.35) LMNAMAPTHTTIL2CYP2D6
SCHEMBL6453741 0.93 MAPT (0.33) LMNAMAPTHTTFASN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6913797-B1 Decahydronaphthalene derivative DAINIPPON INK AND CHEMICALS, INC. (JP) 2005-07-05 — — US disclosed
EP-1108700-A1 DECAHYDRONAPHTHALENE DERIVATIVE DAINIPPON INK AND CHEMICALS, INC. (JP) 2001-06-20 — — EP disclosed