Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 3/20 | 0.70 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.57 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.57 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.57 |
| ▸ | CNR2 | P34972 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MMP3 | P08254 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29381201 | 0.88 | KDM4E (0.68) | CDC25BNR4A1NR4A2NR4A3CNR2 | |
| SCHEMBL43084 | 0.88 | KDM4E (0.68) | CDC25BNR4A1NR4A2NR4A3CNR2 | |
| SCHEMBL29414437 | 0.88 | CDC25B (0.80) | CDC25BNR4A1NR4A2NR4A3CNR2 | |
| SCHEMBL244802 | 0.88 | CDC25B (0.80) | CDC25BNR4A1NR4A2NR4A3CNR2 | |
| Hydrochloric Acid SCHEMBL3149083 | 0.86 | KDM4E (0.66) | CDC25BNR4A1NR4A2NR4A3CNR2 | |
| SCHEMBL18859029 | 0.86 | KDM4E (0.66) | CDC25BNR4A1NR4A2NR4A3CNR2 | |
| SCHEMBL9011545 | 0.86 | KDM4E (0.66) | CDC25BNR4A1NR4A2NR4A3CNR2 | |
| SCHEMBL18859030 | 0.86 | KDM4E (0.66) | CDC25BNR4A1NR4A2NR4A3KDM4E | |
| SCHEMBL14837757 | 0.86 | KDM4E (0.66) | CDC25BNR4A1NR4A2NR4A3CNR2 | |
| Ammonia Solution, Strong SCHEMBL1553414 | 0.86 | KDM4E (0.66) | CDC25BNR4A1NR4A2NR4A3CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | CDC25B 770/4885NR4A1 1035/4885NR4A2 1029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.