Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | FABP7 | O15540 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL308851 | 0.82 | HTT (0.59) | HTTALDH1A1MEN1TSHRKMT2A | |
| Bicarbonate SCHEMBL8238296 | 0.81 | HTT (0.38) | HTTALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL320297 | 0.79 | HTT (0.43) | HTTALDH1A1TSHRHSD17B10TP53 | |
| Acetic Acid SCHEMBL27344367 | 0.79 | HTT (0.39) | HTTFABP7 | |
| Bicarbonate SCHEMBL25258593 | 0.78 | HTT (0.52) | HTTALDH1A1MEN1TSHRKMT2A | |
| Bicarbonate SCHEMBL25297596 | 0.78 | HTT (0.52) | HTTALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL698632 | 0.77 | HTT (0.45) | HTTALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL320668 | 0.77 | HTT (0.45) | HTTALDH1A1FABP7TP53CYP3A4 | |
| SCHEMBL698633 | 0.76 | HTT (0.48) | HTTALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL30181660 | 0.76 | HTT (0.48) | HTTALDH1A1MEN1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823744-B1 | Ionically conductive polymeric gel electrolyte and solid battery containing the same | MITSUI CHEMICALS INC (JP) | 2005-10-12 | — | — | EP | disclosed |
| US-5925283-A | HIGH IONIC CONDUCTIVITY AND HIGH SOLID STRENGTH; CROSSLINKED POLYMER MATRIX, ELECTROLYTIC SALT, AND A NONAQUEOUS ELECTROLYTIC SOLUTION WHICH CONTAINS AT LEAST ONE HALOGEN-SUBSTITUTED CARBONIC ESTER | MITSUI CHEMICALS, INC. (JP) | 1999-07-20 | — | — | US | disclosed |
| EP-0823744-A2 | Ionically conductive polymeric gel electrolyte and solid battery containing the same | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-11 | — | — | EP | disclosed |