SCHEMBL6461668

SCHEMBL6461668

CCOC(=O)N(CCBr)CCBr

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.44
TRPA1 O75762 1/20 0.44
LMNA P02545 2/20 0.39
HSD17B10 Q99714 2/20 0.39
ALOX15 P16050 1/20 0.37
MGAM O43451 1/20 0.37
GAA P10253 1/20 0.37
SI P14410 1/20 0.37
MGAM2 Q2M2H8 1/20 0.37
SOAT1 P35610 1/20 0.37
CA12 O43570 3/20 0.35
CA9 Q16790 3/20 0.35
CA2 P00918 2/20 0.35
CA1 P00915 2/20 0.35
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
APOBEC3A P31941 1/20 0.32
APOBEC3G Q9HC16 1/20 0.32
POLB P06746 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6463761 0.87 ALDH1A1 (0.41) ALDH1A1TRPA1LMNAHSD17B10ALOX15
SCHEMBL10837228 0.85 ALDH1A1 (0.40) ALDH1A1TRPA1LMNAHSD17B10ALOX15
SCHEMBL10839822 0.84 ALDH1A1 (0.39) ALDH1A1TRPA1LMNAHSD17B10ALOX15
SCHEMBL10839288 0.81 ALDH1A1 (0.48) ALDH1A1TRPA1LMNAHSD17B10ALOX15
SCHEMBL10087947 0.81 CA12 (0.46) ALDH1A1TRPA1LMNAHSD17B10ALOX15
Hydrochloric Acid SCHEMBL28190002 0.79 CA12 (0.44) ALDH1A1TRPA1LMNAHSD17B10ALOX15
SCHEMBL9342971 0.79 ALDH1A1 (0.42) ALDH1A1TRPA1LMNAHSD17B10ALOX15
Bromide SCHEMBL9420993 0.78 ALDH1A1 (0.41) ALDH1A1TRPA1LMNAHSD17B10ALOX15
SCHEMBL19197248 0.77 ALDH1A1 (0.40) ALDH1A1TRPA1LMNAHSD17B10ALOX15
SCHEMBL2272442 0.77 ALDH1A1 (0.40) ALDH1A1TRPA1LMNAHSD17B10ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4657285-A Tubular rubber products BRIDGESTONE CORPORATION (JP) 1987-04-14 US claimed
US-10752566-B2 Solvent compositions for use as replacements for slow evaporating solvents TBF ENVIRONMENTAL TECHNOLOGY INC. (CA) 2020-08-25 US disclosed
US-20180362422-A1 SOLVENT COMPOSITIONS FOR USE AS REPLACEMENTS FOR SLOW EVAPORATING SOLVENTS AXEL PLASTICS RESEARCH LABORATORIES, INC. 2018-12-20 US disclosed
US-RE46942-E1 4-piperidinyl compounds for use as tankyrase inhibitors NOVARTIS AG (CH) 2018-07-10 US disclosed
US-RE46942-E1 4-piperidinyl compounds for use as tankyrase inhibitors NOVARTIS AG (CH) 2018-07-10 US disclosed
US-RE46942-E1 4-piperidinyl compounds for use as tankyrase inhibitors NOVARTIS AG (CH) 2018-07-10 US disclosed
US-20180179476-A1 SOLVENT COMPOSITIONS FOR USE AS HEPTANE REPLACEMENTS TBF ENVIRONMENTAL TECHNOLOGY INC. (CA) 2018-06-28 US disclosed
US-20180179129-A1 SOLVENT COMPOSITIONS FOR USE AS HEXANE REPLACEMENTS TBF ENVIRONMENTAL TECHNOLOGY INC. (CA) 2018-06-28 US disclosed
WO-2016193867-A1 SOLVENT COMPOSITIONS FOR USE AS HEXANE REPLACEMENTS TBF ENVIRONMENTAL TECHNOLOGY INC. (CA) 2016-12-08 WO disclosed
US-9181266-B2 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors NOVARTIS AG (CH) 2015-11-10 US disclosed
EP-1235808-A2 TRICYCLIC ANALGESICS WARNER-LAMBERT COMPANY (US) 2002-09-04 EP disclosed
WO-2000075116-A2 TRICYCLIC ANALGESICS WARNER-LAMBERT COMPANY (US) 2000-12-14 WO disclosed
US-5633247-A ANTIARRTHYMIA AGENT MERCK & CO., INC. (US) 1997-05-27 US disclosed
US-5206240-A Antiarrhythmia agents MERCK & CO., INC. (US) 1993-04-27 US disclosed
EP-0431943-A2 Nitrogen-containing spirocycles MERCK & CO. INC. (US) 1991-06-12 EP disclosed
US-4762589-A Method of making a tubular rubber product having a polyamide or polyester resin layer BRIDGESTONE CORPORATION (JP) 1988-08-09 US disclosed
US-4657285-A Tubular rubber products BRIDGESTONE CORPORATION (JP) 1987-04-14 US disclosed
US-4591618-A HIGH STRENGTH BONDING AGENTS BRIDGESTONE TIRE CO., LTD. (JP) 1986-05-27 US disclosed
US-4300970-A Method of bonding vulcanized rubber to resin BRIDGESTONE TIRE COMPANY LIMITED (JP) 1981-11-17 US disclosed
US-4117036-A ANAEROBIC CURABILITY, SEALANTS BRIDGESTONE TIRE COMPANY LIMITED (JP) 1978-09-26 US disclosed