Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | BPTF | Q12830 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6430654 | 1.00 | ALDH1A1 (0.42) | ALDH1A1L3MBTL1HDAC3HDAC8ADRA1B | |
| SCHEMBL6431119 | 0.90 | ALDH1A1 (0.42) | ALDH1A1L3MBTL1HDAC1SMN1; SMN2POLB | |
| SCHEMBL6431123 | 0.90 | ALDH1A1 (0.42) | ALDH1A1L3MBTL1HDAC1SMN1; SMN2POLB | |
| SCHEMBL6430942 | 0.88 | MAPT (0.42) | ALDH1A1L3MBTL1HDAC1LMNASMN1; SMN2 | |
| SCHEMBL6430946 | 0.88 | MAPT (0.42) | ALDH1A1L3MBTL1HDAC1LMNASMN1; SMN2 | |
| SCHEMBL6430630 | 0.82 | KMT2A (0.43) | ALDH1A1L3MBTL1LMNAMEN1KMT2A | |
| SCHEMBL6430629 | 0.82 | KMT2A (0.43) | ALDH1A1L3MBTL1LMNAMEN1KMT2A | |
| SCHEMBL6436217 | 0.82 | MAPT (0.43) | ALDH1A1L3MBTL1LMNAIDO1TDO2 | |
| SCHEMBL6436235 | 0.82 | MAPT (0.43) | ALDH1A1L3MBTL1LMNAIDO1TDO2 | |
| SCHEMBL6431125 | 0.77 | HDAC1 (0.45) | ALDH1A1L3MBTL1ADRA1BHDAC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924289-B2 | Benzyl(Idene)-lactam derivatives, their preparation and their use as selective (ANT) agonists of 5-HT1A- and/or 5-HT1D receptors | PFIZER INC (US) | 2005-08-02 | — | — | US | claimed |
| US-6462048-B2 | 3-(2-(4-METHYLPIPERAZIN-1-YL)-BENZYLIDENE)-1,3-DIHYDRO-INDOL-2-ONE FOR EXAMPLE; USEFUL AS PSYCHOTHERAPEUTIC AGENTS | PFIZER INC. | 2002-10-08 | — | — | US | disclosed |