Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | TNF | P01375 | 5/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | USP19 | O94966 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6030719 | 0.83 | HDAC6 (0.51) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL2947219 | 0.81 | EHMT2 (0.50) | HDAC6TNF | |
| SCHEMBL5562061 | 0.81 | HDAC6 (0.55) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL664005 | 0.81 | HDAC6 (0.55) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL7205402 | 0.81 | HDAC6 (0.51) | HDAC6TNF | |
| SCHEMBL2922474 | 0.80 | TNF (0.54) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL4380759 | 0.80 | HDAC6 (0.51) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL4380760 | 0.80 | HDAC6 (0.51) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL4376874 | 0.79 | HDAC6 (0.53) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL7210734 | 0.79 | HDAC6 (0.53) | HDAC6TNFHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043395-A1 | Combination therapy comprising zd6474 and a taxane | ASTRAZENECA AB (SE) | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043395-A1 | Combination therapy comprising zd6474 and a taxane | ZYX, VEGFA, TEK | HDAC6 858/4885TNF 548/4885HDAC3 2944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.