Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | TERT | O14746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6464620 | 0.97 | HDAC8 (0.40) | HDAC8KDM4ERAB9AMAPTNPC1 | |
| Bromide SCHEMBL6464634 | 0.89 | HDAC8 (0.40) | HDAC8KDM4ERAB9AMAPTNPC1 | |
| SCHEMBL3301501 | 0.87 | HDAC8 (0.41) | HDAC8KDM4ERAB9AMAPTNPC1 | |
| Bromide SCHEMBL6464626 | 0.86 | HDAC8 (0.40) | HDAC8KDM4ERAB9AMAPTNPC1 | |
| Bromide SCHEMBL7942910 | 0.83 | HDAC8 (0.52) | HDAC8KDM4ERAB9AMAPTNPC1 | |
| SCHEMBL153132 | 0.83 | HDAC8 (0.55) | HDAC8KDM4ERAB9AMAPTNPC1 | |
| SCHEMBL29838155 | 0.83 | HDAC8 (0.55) | HDAC8KDM4ERAB9AMAPTNPC1 | |
| Bromide SCHEMBL29400698 | 0.81 | HDAC8 (0.50) | HDAC8KDM4ERAB9AMAPTNPC1 | |
| Iodide SCHEMBL10938374 | 0.81 | KDM4E (0.54) | HDAC8KDM4ERAB9AMAPTNPC1 | |
| Bromide SCHEMBL29396763 | 0.81 | HDAC8 (0.53) | HDAC8KDM4ERAB9AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6905814-B1 | Use of film-forming titanium dioxide dispersions for cleaning and disinfecting surfaces, film-forming titanium dioxide dispersions | RHODIA CHIMIE | 2005-06-14 | — | — | US | claimed |