Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3928875 | 0.86 | CNR1 (0.60) | CNR1NOTUMHTR2AHTR2CSLC6A4 | |
| SCHEMBL3922373 | 0.85 | CNR1 (0.59) | CNR1NOTUMHTR2AHTR2CSLC6A4 | |
| SCHEMBL3930605 | 0.85 | CNR1 (0.59) | CNR1NOTUMHTR2AHTR2CSLC6A4 | |
| SCHEMBL6472514 | 0.85 | CNR1 (0.45) | CNR1NOTUMTRPV4TP53HTT | |
| SCHEMBL3916541 | 0.84 | CNR1 (0.73) | CNR1NOTUMHTR2AHTR2CSLC6A4 | |
| SCHEMBL3919639 | 0.83 | HTR2A (0.53) | CNR1HTR2AHTR2CSLC6A4TRPV4 | |
| SCHEMBL16244661 | 0.82 | NOTUM (0.52) | CNR1NOTUMHTR2AHTR2CSLC6A4 | |
| SCHEMBL15001481 | 0.81 | RORC (0.46) | CNR1HTR2AHTR2CSLC6A4TP53 | |
| SCHEMBL17292053 | 0.80 | RORC (0.51) | CNR1NOTUMHTR2AHTR2CSLC6A4 | |
| SCHEMBL3919267 | 0.79 | CNR1 (0.52) | CNR1NOTUMCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583742-A1 | NOVEL CB 1 RECEPTOUR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004060870-A1 | NOVEL CB 1 RECEPTOUR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-22 | — | — | WO | disclosed |