Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 10/20 | 0.52 |
| ▸ | TNKS | O95271 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1339393 | 0.77 | ALDH1A1 (0.50) | HCRTR1HCRTR2NPC1MAPK1 | |
| SCHEMBL3786710 | 0.75 | NPC1 (0.49) | HCRTR1HCRTR2NPC1MAPK1 | |
| SCHEMBL3544059 | 0.75 | NPC1 (0.49) | HCRTR1HCRTR2NPC1MAPK1 | |
| SCHEMBL17742692 | 0.75 | NPC1 (0.49) | HCRTR1HCRTR2NPC1MAPK1 | |
| SCHEMBL17318606 | 0.75 | MEN1 (0.61) | HCRTR1NPC1 | |
| SCHEMBL27787386 | 0.75 | MYC (0.54) | HCRTR1HCRTR2NPC1MAPK1 | |
| SCHEMBL22383443 | 0.73 | NPC1 (0.46) | HCRTR1TNKSPARP1TNKS2HCRTR2 | |
| SCHEMBL11665769 | 0.73 | ALDH1A1 (0.51) | HCRTR1HCRTR2NPC1MAPK1 | |
| SCHEMBL17773157 | 0.72 | HCRTR1 (0.46) | HCRTR1HCRTR2NPC1MAPK1PDK1 | |
| SCHEMBL27765468 | 0.71 | TP53 (0.51) | HCRTR1TNKSPARP1TNKS2HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1608643-A1 | 6-SULFONAMIDE QUINOLINE AND CHROMENE DERIVATIVE AS ANDROGEN RECEPTOR ANTAGONISTS | Warner-Lambert Company LLC (US) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004083204-A1 | 6-SULFONAMIDE QUINOLINE AND CHROMENE DERIVATIVE AS ANDROGEN RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY LLC (US) | 2004-09-30 | — | — | WO | disclosed |