Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 17/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27600421 | 0.82 | TRPV1 (0.61) | TRPV1 | |
| SCHEMBL27600446 | 0.79 | TRPV1 (0.77) | TRPV1 | |
| SCHEMBL27618912 | 0.74 | TRPV1 (0.58) | TRPV1EPHX2 | |
| SCHEMBL6449846 | 0.72 | TRPV1 (0.69) | TRPV1 | |
| SCHEMBL6465638 | 0.72 | TRPV1 (0.59) | TRPV1 | |
| SCHEMBL27600438 | 0.70 | TRPV1 (0.60) | TRPV1 | |
| SCHEMBL27600558 | 0.70 | TRPV1 (0.62) | TRPV1 | |
| SCHEMBL4972789 | 0.70 | TRPV1 (0.81) | TRPV1 | |
| SCHEMBL27618875 | 0.69 | TRPV1 (0.42) | TRPV1 | |
| SCHEMBL27600463 | 0.69 | TRPV1 (0.55) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581225-A1 | COMBINATION THERAPY FOR THE TREATMENT OF PAIN | NEUROGEN CORPORATION (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004054582-A1 | COMBINATION THERAPY FOR THE TREATMENT OF PAIN | NEUROGEN CORPORATION (US) | 2004-07-01 | — | — | WO | disclosed |