Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 10/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ACP1 | P24666 | 2/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL645676 | 1.00 | KIF11 (0.60) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL646890 | 0.91 | KIF11 (0.73) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL644968 | 0.87 | KIF11 (0.64) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL645263 | 0.87 | KIF11 (0.64) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL2456301 | 0.85 | KIF11 (0.62) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL644051 | 0.85 | KIF11 (0.70) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL646152 | 0.85 | KIF11 (0.65) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL646430 | 0.84 | KIF11 (0.83) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL644014 | 0.84 | KIF11 (0.73) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL645375 | 0.83 | KIF11 (0.65) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119678-B2 | Compounds, compositions and methods | CYTOKINETICS, INCORPORATED (US) | 2012-02-21 | — | — | US | disclosed |