Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6462336 | 0.82 | HDAC1 (0.47) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL6466422 | 0.78 | HDAC6 (0.50) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL6467339 | 0.73 | HDAC1 (0.58) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL27611242 | 0.73 | HPGD (0.69) | HDAC1HDAC3POLBALDH1A1RAB9A | |
| SCHEMBL27628035 | 0.70 | POLB (0.59) | POLBALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL11266573 | 0.68 | POLB (0.60) | POLBALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL9829545 | 0.66 | KDM4E (0.76) | HDAC1HDAC3ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL13751929 | 0.66 | HDAC1 (0.81) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL9274180 | 0.65 | ASAH1 (0.63) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL9830587 | 0.65 | KDM4E (0.73) | HDAC1HDAC3HDAC11HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1516877-A1 | Amine derivatives as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-23 | — | — | EP | disclosed |