Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 5/20 | 0.48 |
| ▸ | SLC2A4 | P14672 | 2/20 | 0.48 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.48 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.48 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | SLC2A8 | Q9NY64 | 1/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6461963 | 0.84 | SLC2A1 (0.57) | PARP1SMN1; SMN2SLC2A1SLC2A4LPAR1 | |
| SCHEMBL11900347 | 0.80 | KMT2A (0.67) | PARP1SLC2A1SLC2A4LPAR1LPAR5 | |
| SCHEMBL711132 | 0.75 | PARP1 (0.61) | TRPM8PARP1RIPK1 | |
| SCHEMBL29448761 | 0.75 | PARP1 (0.61) | TRPM8PARP1RIPK1 | |
| SCHEMBL24343532 | 0.75 | SLC2A1 (0.63) | SMN1; SMN2SLC2A1SLC2A4LPAR1LPAR5 | |
| SCHEMBL7179678 | 0.74 | HSD17B2 (0.56) | PARP1SLC2A1SLC2A4HSD17B2MEN1 | |
| SCHEMBL30246316 | 0.74 | HSD17B2 (0.56) | PARP1SLC2A1SLC2A4HSD17B2MEN1 | |
| SCHEMBL4639564 | 0.74 | MRGPRX4 (0.61) | TRPM8RIPK1 | |
| Hydrochloric Acid SCHEMBL1268771 | 0.74 | PARP1 (0.59) | TRPM8PARP1RIPK1 | |
| SCHEMBL5334251 | 0.74 | MMP13 (0.81) | MMP13HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1530475-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 | Warner-Lambert Company LLC (US) | 2005-05-18 | — | — | EP | disclosed |
| WO-2004006931-A2 | PHARMACEUTICAL COMPOSTIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 | WARNER-LAMBERT COMPANY LLC (US) | 2004-01-22 | — | — | WO | disclosed |