Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.40 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.38 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RXRA | P19793 | 3/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.35 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646789 | 0.93 | CRACR2A (0.41) | CRACR2ATRPC3ORAI1TRPC5POLB | |
| SCHEMBL645672 | 0.87 | CRACR2A (0.41) | CRACR2ATRPC3ORAI1TRPC5POLB | |
| SCHEMBL645712 | 0.86 | POLB (0.41) | CRACR2ATRPC3ORAI1TRPC5POLB | |
| SCHEMBL649245 | 0.84 | STING1 (0.40) | RXRAPPARGNR1H3ACSS2MAPT | |
| SCHEMBL645898 | 0.84 | SMN1; SMN2 (0.41) | CRACR2ARXRAPPARGNR1H3ACSS2 | |
| SCHEMBL648071 | 0.83 | MAPT (0.44) | POLBRXRAPPARGNR1H3MAPT | |
| SCHEMBL646066 | 0.83 | ACSS2 (0.37) | ORAI1RXRAPPARGNR1H3ACSS2 | |
| SCHEMBL648215 | 0.83 | MEN1 (0.40) | POLBRXRAPPARGNR1H3ACSS2 | |
| SCHEMBL646756 | 0.82 | EPHX2 (0.36) | RXRAPPARGNR1H3ACSS2MAPT | |
| SCHEMBL646791 | 0.82 | NPC1 (0.40) | RXRAPPARGNR1H3ACSS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119643-B2 | Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2012-02-21 | — | — | US | claimed |
| US-8119643-B2 | Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2012-02-21 | — | — | US | disclosed |