SCHEMBL6468462

SCHEMBL6468462

O=[C]c1ccc(C(=O)c2ccccc2)c(C(=O)c2ccccc2)c1[C]=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 1/20 0.44
ALDH1A1 P00352 4/20 0.43
GAA P10253 2/20 0.42
KDM4E B2RXH2 2/20 0.42
MEN1 O00255 2/20 0.42
USP2 O75604 2/20 0.42
KMT2A Q03164 2/20 0.42
KEAP1 Q14145 1/20 0.42
NFE2L2 Q16236 1/20 0.42
MAPT P10636 3/20 0.42
CYP2C8 P10632 1/20 0.39
CYP2C9 P11712 1/20 0.39
ATM Q13315 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
SRD5A2 P31213 1/20 0.38
HSD17B10 Q99714 2/20 0.38
MAPK1 P28482 2/20 0.38
ALOX15 P16050 1/20 0.38
MYC P01106 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10375183 0.86 AKR1C3 (0.47) AKR1C3ALDH1A1GAAKDM4EMEN1
SCHEMBL6462550 0.83 ALDH1A1 (0.47) AKR1C3ALDH1A1GAAKMT2AMAPT
SCHEMBL6463241 0.79 ALDH1A1 (0.56) AKR1C3ALDH1A1GAAMEN1KMT2A
SCHEMBL10657458 0.79 AKR1C3 (0.52) AKR1C3ALDH1A1GAAKDM4EMEN1
SCHEMBL1666651 0.77 ALDH1A1 (0.65) AKR1C3ALDH1A1GAAKDM4EMEN1
SCHEMBL1331831 0.76 AKR1C3 (0.57) AKR1C3ALDH1A1GAAKDM4EMEN1
SCHEMBL64069 0.76 AKR1C3 (0.57) AKR1C3ALDH1A1GAAKDM4EMEN1
SCHEMBL10992705 0.75 ALDH1A1 (0.56) AKR1C3ALDH1A1GAAMEN1KMT2A
SCHEMBL10640903 0.72 MEN1 (0.59) AKR1C3ALDH1A1GAAKDM4EMEN1
SCHEMBL4376001 0.71 POLB (0.49) AKR1C3GAAMAPTMAPK1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6951904-B1 Process for increasing the melt strength of polypropylene POLYMERS AUSTRALIA PTY LIMITED (AU) 2005-10-04 US claimed
EP-1080148-A4 PROCESS FOR INCREASING THE MELT STRENGTH OF POLYPROPYLENE POLYMERS AUSTRALIA PTY LTD (AU) 2003-02-05 EP claimed
EP-1080148-A1 PROCESS FOR INCREASING THE MELT STRENGTH OF POLYPROPYLENE Polymers Australia PTY Limited (AU) 2001-03-07 EP claimed
WO-1999036466-A1 PROCESS FOR INCREASING THE MELT STRENGTH OF POLYPROPYLENE POLYMERS AUSTRALIA PTY LIMITED (AU) 1999-07-22 WO claimed
US-6951904-B1 Process for increasing the melt strength of polypropylene POLYMERS AUSTRALIA PTY LIMITED (AU) 2005-10-04 US disclosed
EP-1080148-A4 PROCESS FOR INCREASING THE MELT STRENGTH OF POLYPROPYLENE POLYMERS AUSTRALIA PTY LTD (AU) 2003-02-05 EP disclosed
EP-1080148-A1 PROCESS FOR INCREASING THE MELT STRENGTH OF POLYPROPYLENE Polymers Australia PTY Limited (AU) 2001-03-07 EP disclosed
WO-1999036466-A1 PROCESS FOR INCREASING THE MELT STRENGTH OF POLYPROPYLENE POLYMERS AUSTRALIA PTY LIMITED (AU) 1999-07-22 WO disclosed