Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 5/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.31 |
| ▸ | TSHR | P16473 | 4/20 | 0.31 |
| ▸ | HTT | P42858 | 4/20 | 0.31 |
| ▸ | PKM | P14618 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6467155 | 0.94 | BACE1 (0.39) | BACE1BACE2CA12CA1CA7 | |
| SCHEMBL2727491 | 0.93 | BACE1 (0.46) | BACE1BACE2CA12CA1CA7 | |
| SCHEMBL2727492 | 0.93 | BACE1 (0.46) | BACE1BACE2CA12CA1CA7 | |
| SCHEMBL2725260 | 0.87 | BACE1 (0.45) | BACE1BACE2CA12CA1CA7 | |
| SCHEMBL2725259 | 0.87 | BACE1 (0.45) | BACE1BACE2CA12CA1CA7 | |
| SCHEMBL12578538 | 0.84 | BACE1 (0.46) | BACE1BACE2CA12CA1CA7 | |
| SCHEMBL2728124 | 0.83 | NPSR1 (0.35) | BACE1BACE2CA12CA1CA7 | |
| SCHEMBL6467780 | 0.83 | NPSR1 (0.35) | BACE1BACE2CA12CA1CA7 | |
| SCHEMBL2728126 | 0.83 | NPSR1 (0.35) | BACE1BACE2CA12CA1CA7 | |
| SCHEMBL12578585 | 0.81 | BACE1 (0.43) | BACE1BACE2CA12CA1CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |