Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3122580 | 0.80 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DIRAK4 | |
| SCHEMBL6465669 | 0.76 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6469266 | 0.76 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6470116 | 0.75 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6527339 | 0.75 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6470078 | 0.74 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6533002 | 0.72 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1157730 | 0.69 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3130695 | 0.69 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3129573 | 0.68 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569908-A2 | PYRIDINE N-OXIDE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004046113-A2 | PYRIDINE N-OXIDE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-06-03 | — | — | WO | disclosed |