Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6533002 | 0.94 | PDE4A (0.46) | PDE4AALDH1A1PDE4DPDE4BPDE4C | |
| SCHEMBL6530112 | 0.90 | PDE4A (0.42) | PDE4AALDH1A1PDE4DPDE4BPDE4C | |
| SCHEMBL6528128 | 0.86 | ALDH1A1 (0.41) | PDE4AALDH1A1PDE4DPDE4BPDE4C | |
| SCHEMBL2924797 | 0.83 | PDE4A (0.47) | PDE4AALDH1A1S1PR1S1PR3PDE4D | |
| SCHEMBL1157355 | 0.82 | PDE4A (0.51) | PDE4AALDH1A1S1PR1S1PR3PDE4D | |
| SCHEMBL6465669 | 0.80 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6469266 | 0.79 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL2924989 | 0.79 | PDE4A (0.46) | PDE4AALDH1A1PDE4DPDE4BPDE4C | |
| SCHEMBL1157468 | 0.78 | PDE4A (0.51) | PDE4AALDH1A1PDE4DPDE4BPDE4C | |
| SCHEMBL6469942 | 0.78 | PDE4D (0.48) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569908-A2 | PYRIDINE N-OXIDE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004046113-A2 | PYRIDINE N-OXIDE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-06-03 | — | — | WO | disclosed |