Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 4/20 | 0.34 |
| ▸ | WHR1 | P49842 | 2/20 | 0.34 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6470339 | 0.86 | BRAF (0.40) | MAPTALDH1A1BRAFHSD17B10AURKA | |
| Trifluoroacetic Acid SCHEMBL6469042 | 0.85 | WHR1 (0.37) | WHR1EHMT2MAPTALDH1A1HSD17B10 | |
| Trifluoroacetic Acid SCHEMBL6469122 | 0.85 | WHR1 (0.37) | WHR1EHMT2MAPTALDH1A1HSD17B10 | |
| Trifluoroacetic Acid SCHEMBL6470145 | 0.85 | MAPT (0.36) | WHR1EHMT2MAPTALDH1A1HSD17B10 | |
| Trifluoroacetic Acid SCHEMBL6469336 | 0.83 | MAPT (0.37) | WHR1EHMT2MAPTALDH1A1HSD17B10 | |
| Trifluoroacetic Acid SCHEMBL6467995 | 0.83 | FGFR2 (0.41) | WHR1EHMT2ADORA2AMAPTALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL6468643 | 0.83 | MEN1 (0.38) | ALDH1A1HSD17B10KDM4EMEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL6466263 | 0.83 | MAPT (0.40) | WHR1EHMT2MAPTALDH1A1BRAF | |
| Trifluoroacetic Acid SCHEMBL6467465 | 0.83 | MAPT (0.39) | WHR1EHMT2MAPTALDH1A1HSD17B10 | |
| Trifluoroacetic Acid SCHEMBL6470209 | 0.82 | MAPT (0.39) | WHR1EHMT2MAPTALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124562-A1 | Bis-quinazoline compounds for the treatment of bacterial infections | REPLIDYNE, INC. | 2005-06-09 | — | — | US | claimed |
| WO-2005030131-A2 | BIS-QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | REPLIDYNE, INC (US) | 2005-04-07 | — | — | WO | claimed |
| US-20050124562-A1 | Bis-quinazoline compounds for the treatment of bacterial infections | REPLIDYNE, INC. | 2005-06-09 | — | — | US | disclosed |
| WO-2005030131-A2 | BIS-QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | REPLIDYNE, INC (US) | 2005-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124562-A1 | Bis-quinazoline compounds for the treatment of bacterial infections | POLI, POLK, POLB | ADORA2B 4191/4885WHR1 4034/4885EHMT2 2664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.