Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.40 |
| ▸ | BID | P55957 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.38 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10894648 | 0.97 | KCNH2 (0.49) | KCNH2SIGMAR1LIPGHTR2AEP300 | |
| SCHEMBL5332631 | 0.95 | KCNH2 (0.40) | KCNH2SIGMAR1LIPGHTR2ACYSLTR2 | |
| SCHEMBL981449 | 0.89 | LIPG (0.47) | KCNH2LIPGCYSLTR2CYSLTR1BID | |
| SCHEMBL980262 | 0.89 | LIPG (0.47) | KCNH2LIPGCYSLTR2CYSLTR1BID | |
| SCHEMBL983670 | 0.89 | LIPG (0.47) | KCNH2LIPGCYSLTR2CYSLTR1BID | |
| SCHEMBL9016158 | 0.89 | LIPG (0.47) | KCNH2LIPGCYSLTR2CYSLTR1BID | |
| SCHEMBL815963 | 0.89 | LIPG (0.47) | KCNH2LIPGCYSLTR2CYSLTR1BID | |
| SCHEMBL983961 | 0.89 | LIPG (0.47) | KCNH2LIPGCYSLTR2CYSLTR1BID | |
| SCHEMBL21523344 | 0.87 | LIPG (0.49) | KCNH2LIPGCYSLTR2CYSLTR1BID | |
| SCHEMBL21523328 | 0.87 | LIPG (0.49) | KCNH2LIPGCYSLTR2CYSLTR1BID |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005037797-A1 | SUBSTITUTED PYRAZOLE UREA COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2005-04-28 | — | — | WO | claimed |