Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 4/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 7/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.37 |
| ▸ | LATS1 | O95835 | 1/20 | 0.33 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4628396 | 0.79 | FYN (0.47) | FYNHCAR3HCAR2CDK2CCNA2 | |
| SCHEMBL6469193 | 0.79 | SCN9A (0.41) | SCN9ASCN5AKCNH2CDK2 | |
| SCHEMBL5414326 | 0.78 | FYN (0.46) | FYNHCAR3HCAR2CDK2CCNA2 | |
| SCHEMBL4628001 | 0.78 | FYN (0.46) | FYNHCAR3HCAR2CDK2CCNA2 | |
| SCHEMBL5416416 | 0.75 | FYN (0.44) | FYNHCAR3HCAR2CDK2CCNA2 | |
| SCHEMBL6468902 | 0.75 | FYN (0.46) | FYNSCN9AKCNH2HCAR3HCAR2 | |
| SCHEMBL5042272 | 0.75 | SCN9A (0.41) | SCN9ASCN5AKCNH2HCAR3CDK2 | |
| SCHEMBL6469127 | 0.72 | TLR8 (0.53) | SCN9ASCN5AKCNH2HCAR3CDK2 | |
| SCHEMBL13159701 | 0.71 | — | — | |
| SCHEMBL3193118 | 0.70 | TLR8 (0.47) | SCN9ASCN5AKCNH2HCAR3LATS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | PFIZER, INC. | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | APP, BACE1, SNCA | FYN 667/4885SCN9A 666/4885SCN5A 1919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.