Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 3/20 | 0.47 |
| ▸ | CRHR1 | P34998 | 8/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | LATS1 | O95835 | 1/20 | 0.34 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784282 | 0.87 | FYN (0.41) | FYNCRHR1HCAR3HCAR2CCNA2 | |
| SCHEMBL21140560 | 0.85 | FYN (0.38) | FYNCRHR1CCNA2CDK2CCNA1 | |
| SCHEMBL4628001 | 0.79 | FYN (0.46) | FYNCRHR1HCAR3HCAR2CCNA2 | |
| SCHEMBL6468910 | 0.79 | FYN (0.51) | FYNCRHR1HCAR3HCAR2CCNA2 | |
| SCHEMBL5414326 | 0.79 | FYN (0.46) | FYNCRHR1HCAR3HCAR2CCNA2 | |
| SCHEMBL15357781 | 0.78 | TRPM8 (0.41) | HCAR3DYRK1A | |
| SCHEMBL4935809 | 0.77 | FYN (0.35) | FYNCRHR1HCAR3HCAR2 | |
| SCHEMBL5416416 | 0.77 | FYN (0.44) | FYNCRHR1HCAR3HCAR2CCNA2 | |
| SCHEMBL12497287 | 0.74 | GRM5 (0.35) | HCAR3 | |
| SCHEMBL19121474 | 0.73 | CRHR1 (0.65) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1734820-A4 | IMIDAZOPYRAZINES, IMIDAZOPYRIDINES, AND IMIDAZOPYRIMIDINES AS CRF1 RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2008-01-23 | — | — | EP | disclosed |
| EP-1734820-A2 | IMIDAZOPYRAZINES, IMIDAZOPYRIDINES, AND IMIDAZOPYRIMIDINES AS CRF1 RECEPTOR LIGANDS | Neurogen Corporation (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005115399-A2 | IMIDAZOPYRAZINES, IMIDAZOPYRIDINES, ANS IMIDAZOPYRIMIDINES AS CRF1 RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2005-12-08 | — | — | WO | disclosed |