Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 1/20 | 0.47 |
| ▸ | GRM6 | O15303 | 1/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.47 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5840973 | 1.00 | GRM8 (0.47) | GRM8GRM6GRM2GRM3SLC1A2 | |
| SCHEMBL5840977 | 0.84 | GRM8 (0.47) | GRM8GRM6GRM2GRM3SLC1A2 | |
| SCHEMBL6469153 | 0.84 | GRM8 (0.47) | GRM8GRM6GRM2GRM3SLC1A2 | |
| Hydrochloric Acid SCHEMBL5843002 | 0.80 | GRM2 (0.47) | GRM8GRM6GRM2GRM3SLC1A2 | |
| SCHEMBL5840776 | 0.80 | SLC1A2 (0.48) | GRM8GRM6GRM2GRM3SLC1A2 | |
| Hydrochloric Acid SCHEMBL5840768 | 0.79 | SLC1A2 (0.47) | GRM8GRM6GRM2GRM3SLC1A2 | |
| Hydrochloric Acid SCHEMBL5841578 | 0.77 | GRM2 (0.47) | GRM8GRM6GRM2GRM3SLC1A2 | |
| Hydrochloric Acid SCHEMBL5841620 | 0.76 | GRM2 (0.46) | GRM8GRM6GRM2GRM3SLC1A2 | |
| Hydrochloric Acid SCHEMBL6465474 | 0.76 | GRM2 (0.46) | GRM8GRM6GRM2GRM3SLC1A2 | |
| Hydrochloric Acid SCHEMBL5841613 | 0.76 | GRM2 (0.46) | GRM8GRM6GRM2GRM3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009912-A1 | Prodrugs of excitatory amino acids | ELI LILLY AND COMPANY | 2005-01-13 | — | — | US | disclosed |
| US-20040138304-A1 | Prodrugs of excitatory amino acids | ELI LILLY AND COMPANY | 2004-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009912-A1 | Prodrugs of excitatory amino acids | SLC1A2, SLC1A3, SLC1A1 | GRM8 46/4885GRM6 39/4885GRM2 19/4885 |
| US-20040138304-A1 | Prodrugs of excitatory amino acids | SLC1A2, SLC1A1, SLC1A3 | GRM8 44/4885GRM6 27/4885GRM2 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.