Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.43 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.37 |
| ▸ | PRKACA | P17612 | 5/20 | 0.37 |
| ▸ | GSK3B | P49841 | 5/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.37 |
| ▸ | CLK2 | P49760 | 4/20 | 0.37 |
| ▸ | GSK3A | P49840 | 4/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.37 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.37 |
| ▸ | CDK2 | P24941 | 4/20 | 0.37 |
| ▸ | CDC7 | O00311 | 4/20 | 0.37 |
| ▸ | CDK1 | P06493 | 3/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7885565 | 0.78 | MAPK1 (0.39) | BRAFTNNI3KMAPK1CHEK1IRAK4 | |
| SCHEMBL868756 | 0.76 | RET (0.41) | BRAFTNNI3KMAPK1CHEK1IRAK4 | |
| SCHEMBL154600 | 0.74 | CHEK1 (0.61) | BRAFTNNI3KMAPK1CHEK1DYRK1A | |
| SCHEMBL19306619 | 0.74 | BRAF (0.41) | BRAFTNNI3KMAPK1CHEK1IRAK4 | |
| SCHEMBL4006360 | 0.74 | BRAF (0.60) | BRAFTNNI3KMAPK1IRAK4MAP4K4 | |
| SCHEMBL31706714 | 0.73 | BTK (0.40) | BRAFTNNI3KMAPK1CHEK1IRAK4 | |
| SCHEMBL10110415 | 0.73 | AKT1 (0.39) | BRAFTNNI3KMAPK1CHEK1IRAK4 | |
| SCHEMBL31705805 | 0.72 | BRAF (0.40) | BRAFTNNI3KIRAK4MAP4K4PRKACA | |
| SCHEMBL17208093 | 0.71 | BTK (0.44) | BRAFTNNI3KMAP4K4CDK1RPS6KB1 | |
| SCHEMBL4005872 | 0.70 | PDPK1 (0.40) | BRAFTNNI3KMAPK1CHEK1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050203063-A1 | Proteasome pathway inhibitors and related methods | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203063-A1 | Proteasome pathway inhibitors and related methods | PSME1, PSMC5, PSMB1 | BRAF 1348/4885TNNI3K 991/4885MAPK1 565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.