Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 13/20 | 0.72 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.72 |
| ▸ | RAB9A | P51151 | 10/20 | 0.70 |
| ▸ | NPC1 | O15118 | 9/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12196166 | 0.84 | EPHX1 (1.00) | EPHX1EPHX2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8867977 | 0.81 | RAB9A (0.72) | EPHX1EPHX2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6567248 | 0.81 | RAB9A (0.72) | EPHX1EPHX2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2753564 | 0.81 | NPC1 (0.97) | EPHX1EPHX2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6470046 | 0.81 | RAB9A (0.57) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL822967 | 0.80 | RAB9A (0.78) | EPHX1EPHX2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13886418 | 0.80 | RAB9A (0.69) | EPHX1EPHX2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13756244 | 0.79 | EPHX1 (0.86) | EPHX1EPHX2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13712777 | 0.78 | RAB9A (0.75) | EPHX1EPHX2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL23939301 | 0.78 | RAB9A (0.74) | EPHX1EPHX2RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531811-A2 | DERIVATIVES OF 3-HYDROXY-4-(CYCLYL-ALKYLAMINOALKYL)-5-PHENYL-1H-PYRAZOLE AS ANTAGONISTS OF THE GONADOTROPIN RELEASING HORMONE (GNRH) FOR USE IN THE TREATMENT OF SEX HORMONE RELATED CONDITIONS, SUCH AS PROSTATIC OF UTERINE CANCER | AstraZeneca AB (SE) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004017961-A2 | DERIVATIVES OF 3-HYDROXY-4-(CYCLYL-ALKYLAMINOALKYL)-5-PHENYL-1H-PYRAZOLE AS ANTAGONISTS OF THE GONADOTROPIN RELEASING HORMONE (GNRH) FOR USE IN THE TREATMENT OF SEX HORMONE RELATED CONDITIONS, SUCH AS PROSTATIC OF UTERINE CANCER | ASTRAZENECA AB (SE) | 2004-03-04 | — | — | WO | disclosed |