Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | FASN | P49327 | 1/20 | 0.45 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3819125 | 0.87 | CES1 (0.54) | SMN1; SMN2MAPTL3MBTL1HPGDALDH1A1 | |
| SCHEMBL13246765 | 0.83 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTL3MBTL1HPGDRAB9A | |
| SCHEMBL8237871 | 0.83 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTL3MBTL1HPGDRAB9A | |
| SCHEMBL10711163 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTL3MBTL1HPGDRAB9A | |
| SCHEMBL257751 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTL3MBTL1HPGDRAB9A | |
| SCHEMBL29242363 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTL3MBTL1HPGDRAB9A | |
| SCHEMBL29242313 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTL3MBTL1HPGDRAB9A | |
| SCHEMBL28586886 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTL3MBTL1HPGDRAB9A | |
| SCHEMBL7627922 | 0.79 | PDCD1 (0.50) | SMN1; SMN2MAPTL3MBTL1HPGDRXRA | |
| SCHEMBL8995326 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTL3MBTL1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532109-A1 | PYRROLIDINE DERIVATIVES AS OXYTOCIN ANTAGONISTS | Applied Research Systems ARS Holding N.V. (AN) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004005249-A1 | PYRROLIDINE DERIVATIVES AS OXYTOCIN ANTAGONISTS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-01-15 | — | — | WO | disclosed |