Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.53 |
| ▸ | PPARA | Q07869 | 2/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 2/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL919514 | 1.00 | PPARG (0.53) | PPARGPPARAPTGS1PTGS2ALOX5 | |
| SCHEMBL6470614 | 0.86 | MAOB (0.61) | PPARGPPARAPTGS1PTGS2ALOX5 | |
| SCHEMBL6470616 | 0.86 | MAOB (0.61) | PPARGPPARAPTGS1PTGS2ALOX5 | |
| SCHEMBL918652 | 0.86 | MAOB (0.61) | PPARGPPARAPTGS1PTGS2ALOX5 | |
| SCHEMBL918394 | 0.86 | PPARG (0.51) | PPARGPPARAPTGS1PTGS2ALOX5 | |
| SCHEMBL6469802 | 0.86 | PPARG (0.51) | PPARGPPARAPTGS1PTGS2ALOX5 | |
| SCHEMBL6471008 | 0.83 | PTGS1 (0.58) | PPARGPPARAPTGS1PTGS2ALOX5 | |
| SCHEMBL6450459 | 0.83 | PTGS1 (0.58) | PPARGPPARAPTGS1PTGS2ALOX5 | |
| SCHEMBL919180 | 0.83 | PTGS1 (0.58) | PPARGPPARAPTGS1PTGS2ALOX5 | |
| SCHEMBL18648480 | 0.83 | LCK (0.61) | PTGS1ALOX5NQO2APPCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554236-A1 | NOVEL BIOACTIVE DIPHENYL ETHENE COMPOUNDS AND THEIR THERAPEUTIC APPLICATIONS | Welichem Biotech Inc. (CA) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004031117-A1 | NOVEL BIOACTIVE DIPHENYL ETHENE COMPOUNDS AND THEIR THERAPEUTIC APPLICATIONS | WELICHEM BIOTECH INC. (CA) | 2004-04-15 | — | — | WO | disclosed |