SCHEMBL6450459

SCHEMBL6450459

CCCc1c(O)cc(/C=C/c2ccc(F)cc2F)cc1O

nearest known ligand 0.58

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 4/20 0.58
PTGS2 P35354 3/20 0.58
NFE2L2 Q16236 5/20 0.53
HTR2A P28223 4/20 0.44
HTR2C P28335 4/20 0.44
KCNH2 Q12809 2/20 0.44
PPARG P37231 2/20 0.40
PPARA Q07869 2/20 0.40
CYP1A1 P04798 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP1B1 Q16678 1/20 0.39
ALOX5 P09917 1/20 0.36
POLB P06746 1/20 0.36
MAPT P10636 1/20 0.36
RAB9A P51151 1/20 0.36
NR3C2 P08235 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL919180 1.00 PTGS1 (0.58) PTGS1PTGS2NFE2L2HTR2AHTR2C
SCHEMBL6471008 1.00 PTGS1 (0.58) PTGS1PTGS2NFE2L2HTR2AHTR2C
SCHEMBL918502 0.84 NFE2L2 (0.51) PTGS1PTGS2NFE2L2
SCHEMBL6465417 0.84 NFE2L2 (0.51) PTGS1PTGS2NFE2L2
SCHEMBL6465420 0.84 NFE2L2 (0.51) PTGS1PTGS2NFE2L2
SCHEMBL6469970 0.83 PPARG (0.53) PTGS1PTGS2NFE2L2PPARGPPARA
SCHEMBL919514 0.83 PPARG (0.53) PTGS1PTGS2NFE2L2PPARGPPARA
SCHEMBL6450483 0.81 PPARG (0.41) PTGS1PTGS2PPARGPPARAALOX5
SCHEMBL6450486 0.81 PPARG (0.41) PTGS1PTGS2PPARGPPARAALOX5
SCHEMBL6311612 0.81 PPARG (0.41) PTGS1PTGS2PPARGPPARAALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1554236-A1 NOVEL BIOACTIVE DIPHENYL ETHENE COMPOUNDS AND THEIR THERAPEUTIC APPLICATIONS Welichem Biotech Inc. (CA) 2005-07-20 EP claimed
WO-2004031117-A1 NOVEL BIOACTIVE DIPHENYL ETHENE COMPOUNDS AND THEIR THERAPEUTIC APPLICATIONS WELICHEM BIOTECH INC. (CA) 2004-04-15 WO claimed
EP-1554236-A1 NOVEL BIOACTIVE DIPHENYL ETHENE COMPOUNDS AND THEIR THERAPEUTIC APPLICATIONS Welichem Biotech Inc. (CA) 2005-07-20 EP disclosed
WO-2004031117-A1 NOVEL BIOACTIVE DIPHENYL ETHENE COMPOUNDS AND THEIR THERAPEUTIC APPLICATIONS WELICHEM BIOTECH INC. (CA) 2004-04-15 WO disclosed