Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6470260 | 0.91 | TP53 (0.42) | MAPTTP53NPSR1POLBRAD52 | |
| Trifluoroacetic Acid SCHEMBL6470334 | 0.80 | ABCG2 (0.42) | MAPTTP53POLBRAD52MEN1 | |
| Acetic Acid SCHEMBL6469268 | 0.79 | SMN1; SMN2 (0.42) | MAPTTP53NPSR1POLBRAD52 | |
| SCHEMBL6467464 | 0.78 | ADORA2B (0.43) | MAPTTP53NPSR1POLBRAD52 | |
| SCHEMBL6470113 | 0.78 | MAPT (0.51) | MAPTTP53NPSR1POLBRAD52 | |
| SCHEMBL6469370 | 0.77 | ABCG2 (0.44) | MAPTTP53NPSR1POLBRAD52 | |
| SCHEMBL6465723 | 0.76 | TP53 (0.45) | MAPTTP53POLBRAD52EGFR | |
| Trifluoroacetic Acid SCHEMBL6467192 | 0.76 | WHR1 (0.41) | MAPTTP53POLBRAD52MEN1 | |
| Hydrochloric Acid SCHEMBL6470480 | 0.76 | SLC2A1 (0.45) | MAPTTP53NPSR1POLBRAD52 | |
| Trifluoroacetic Acid SCHEMBL6469755 | 0.74 | KMT2A (0.40) | MAPTTP53NPSR1POLBRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124562-A1 | Bis-quinazoline compounds for the treatment of bacterial infections | REPLIDYNE, INC. | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124562-A1 | Bis-quinazoline compounds for the treatment of bacterial infections | POLI, POLK, POLB | MAPT 3552/4885TP53 1339/4885NPSR1 4093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.