Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 8/20 | 0.53 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.52 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.49 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.49 |
| ▸ | TLR4 | O00206 | 5/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | GABRP | O00591 | 2/20 | 0.46 |
| ▸ | GABRD | O14764 | 2/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.46 |
| ▸ | GABRE | P78334 | 2/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.46 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6472027 | 0.87 | ADRB2 (0.58) | ADRB2DNM1IMPDH2IMPDH1TLR4 | |
| SCHEMBL30692087 | 0.84 | ADRB2 (0.59) | ADRB2DNM1IMPDH2IMPDH1TLR4 | |
| SCHEMBL6009074 | 0.83 | ADRB2 (0.57) | ADRB2DNM1IMPDH2IMPDH1TLR4 | |
| SCHEMBL4052917 | 0.81 | ADRB2 (0.67) | ADRB2DNM1TLR4DRD2ADRB1 | |
| SCHEMBL30493558 | 0.80 | ADRB2 (0.58) | ADRB2DNM1IMPDH2IMPDH1TLR4 | |
| SCHEMBL14046114 | 0.80 | ADRB2 (0.61) | ADRB2DNM1IMPDH2IMPDH1TLR4 | |
| SCHEMBL6925186 | 0.80 | ADRB2 (0.58) | ADRB2DNM1IMPDH2IMPDH1TLR4 | |
| SCHEMBL4893406 | 0.80 | SRD5A2 (0.56) | ADRB2DNM1IMPDH2IMPDH1TLR4 | |
| SCHEMBL4627007 | 0.79 | ADRB2 (0.60) | ADRB2DNM1IMPDH2IMPDH1TLR4 | |
| SCHEMBL6921090 | 0.79 | ADRB2 (0.50) | ADRB2DNM1IMPDH2IMPDH1TLR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554262-A1 | NOVEL TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Glenmark Pharmaceuticals Limited (IN) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004037805-A1 | NOVEL TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-05-06 | — | — | WO | disclosed |