Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 5/20 | 0.44 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6531788 | 0.93 | PLA2G2A (0.42) | PLA2G2AP2RX4MAPTPPARGP2RX7 | |
| SCHEMBL6470628 | 0.92 | P2RX4 (0.41) | PLA2G2AP2RX4MAPTPPARGP2RX7 | |
| SCHEMBL6471446 | 0.92 | PIK3R1 (0.47) | PLA2G2AP2RX4MAPTP2RX7PIK3R1 | |
| SCHEMBL6471021 | 0.84 | AR (0.39) | PLA2G2AMAPTPPARGP2RX7AR | |
| SCHEMBL6472462 | 0.75 | PLA2G2A (0.48) | PLA2G2A | |
| SCHEMBL5018007 | 0.75 | PLA2G2A (0.42) | PLA2G2AMAPTPPARGARPIK3R1 | |
| SCHEMBL5023371 | 0.74 | AR (0.43) | PLA2G2AP2RX4MAPTPPARGAR | |
| SCHEMBL5026662 | 0.74 | PIK3R1 (0.45) | PLA2G2AMAPTARPIK3R1PIK3CA | |
| SCHEMBL5022811 | 0.74 | MAPT (0.45) | PLA2G2AP2RX4MAPTPPARGP2RX7 | |
| SCHEMBL6471402 | 0.73 | PDE4B (0.44) | PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554262-A1 | NOVEL TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Glenmark Pharmaceuticals Limited (IN) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004037805-A1 | NOVEL TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-05-06 | — | — | WO | disclosed |