Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6471083 | 0.86 | NR4A2 (0.61) | MAOBNR4A2MAOAKMT2AMRGPRX4 | |
| SCHEMBL6526454 | 0.84 | MAOB (0.55) | MAOBNR4A2MAOAKMT2AMRGPRX4 | |
| SCHEMBL28431858 | 0.79 | ADAMTS4 (0.56) | MAOBNR4A2PKM | |
| SCHEMBL15340853 | 0.77 | MAOB (0.65) | MAOBNR4A2MAOAKMT2AMEN1 | |
| SCHEMBL28430701 | 0.77 | ADAMTS4 (0.54) | MAOBNR4A2KMT2ALMNA | |
| SCHEMBL6472275 | 0.77 | MAOB (0.60) | MAOBNR4A2MAOAKMT2AMEN1 | |
| SCHEMBL15084962 | 0.77 | HDAC4 (0.50) | KMT2ALMNAALDH1A1MAPTRAB9A | |
| SCHEMBL28424798 | 0.76 | ADAMTS4 (0.52) | MAOBNR4A2 | |
| SCHEMBL6415086 | 0.76 | MAOB (0.75) | MAOBNR4A2MAOAKMT2AMRGPRX4 | |
| SCHEMBL28427154 | 0.75 | KMT2A (0.48) | MAOBNR4A2KMT2AMRGPRX4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501804-A1 | ISOQUINOLINE DERIVATIVES MAO-B INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003091219-A1 | ISOQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-06 | — | — | WO | disclosed |