Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 5/20 | 0.35 |
| ▸ | TACR3 | P29371 | 4/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.31 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637744 | 0.91 | TACR1 (0.40) | TACR1TACR3CCR2TSHRALDH1A1 | |
| SCHEMBL4638014 | 0.85 | GPBAR1 (0.40) | TACR1TACR3TSHRGPBAR1ALDH1A1 | |
| SCHEMBL4706457 | 0.81 | ALDH1A1 (0.44) | TACR1TSHRGPBAR1ALDH1A1RECQL | |
| SCHEMBL4637876 | 0.76 | EPAS1 (0.39) | TACR1TSHRGPBAR1ALDH1A1RECQL | |
| SCHEMBL4637937 | 0.75 | IDH1 (0.43) | TSHRGPBAR1ALDH1A1RECQLMAPT | |
| SCHEMBL4637796 | 0.74 | EPAS1 (0.39) | TACR1TACR3TSHRGPBAR1ALDH1A1 | |
| SCHEMBL4638603 | 0.74 | ALDH1A1 (0.44) | TACR1TSHRGPBAR1ALDH1A1RECQL | |
| SCHEMBL4707134 | 0.73 | EPAS1 (0.40) | TACR1TSHRGPBAR1ALDH1A1RECQL | |
| SCHEMBL4637783 | 0.73 | TACR1 (0.41) | TACR1TSHRGPBAR1ALDH1A1RECQL | |
| SCHEMBL4638045 | 0.73 | EPAS1 (0.39) | TACR1TSHRGPBAR1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-A1 | TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-02-02 | — | — | EP | claimed |
| WO-2003091227-A1 | TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2003-11-06 | — | — | WO | claimed |