Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | GPR3 | P46089 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28157946 | 0.76 | PTPRC (0.38) | MAPTKMT2ASMN1; SMN2MEN1LMNA | |
| SCHEMBL28158295 | 0.76 | CHEK1 (0.38) | GAAGPR3MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL29353131 | 0.75 | MAPT (0.41) | GAAMAPTKMT2AMEN1LMNA | |
| SCHEMBL156862 | 0.75 | MAPT (0.41) | GAAMAPTKMT2AMEN1LMNA | |
| SCHEMBL8162709 | 0.74 | CYP1A2 (0.47) | GAAGPR3MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL27692616 | 0.71 | CA1 (0.48) | GAAMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL25138231 | 0.68 | NOX1 (0.56) | GAAGPR3MAPTKMT2ASMN1; SMN2 | |
| Piperazine SCHEMBL20876223 | 0.68 | MAPT (0.34) | GAAMAPTKMT2AMEN1LMNA | |
| SCHEMBL10395049 | 0.68 | HDAC4 (0.41) | GAAGPR3MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL31669020 | 0.67 | GPR3 (0.59) | GPR3MAPTKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513816-A2 | METHOD OF PREPARING A 5H-DIBENZ(B,F)AZEPINE-5-CARBOXAMIDE | TARO PHARMACEUTICALS U.S.A., INC. (US) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003106414-A2 | METHOD OF PREPARING A 5H-DIBENZ[B,F]AZEPINE-5-CARBOXAMIDE | TARO PHARMACEUTICALS U.S.A., INC. (US) | 2003-12-24 | — | — | WO | disclosed |