Sugi Predict

Sugi Predict / Compounds / SCHEMBL6472203

SCHEMBL6472203

SCHEMBL6472203

Cc1[nH]c(=O)c(Cl)c(OCc2ccc(F)cc2F)c1Cc1ccc(C(=O)N(C)C)cc1

nearest known ligand 0.57

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ MAPK14 Q16539 16/20 0.57
▸ PTGER1 P34995 2/20 0.43
▸ MAOB P27338 1/20 0.41
▸ PARP1 P09874 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6471580 0.90 MAPK14 (0.45) MAPK14PTGER1MAOB
SCHEMBL6471516 0.89 MAPK14 (0.51) MAPK14PTGER1MAOB
SCHEMBL4377468 0.88 MAPK14 (0.43) MAPK14MAOB
SCHEMBL6471631 0.83 MAPK14 (0.59) MAPK14
SCHEMBL6471507 0.83 MAPK14 (0.41) MAPK14MAOB
SCHEMBL6471919 0.81 MAPK14 (0.40) MAPK14MAOBPARP1
SCHEMBL6471719 0.80 MAPK14 (0.42) MAPK14PTGER1
Hydrochloric Acid SCHEMBL6473516 0.80 MAPK14 (0.39) MAPK14MAOB
SCHEMBL6471706 0.79 MAPK14 (0.45) MAPK14MAOB
Hydrochloric Acid SCHEMBL6472010 0.79 MAPK14 (0.46) MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3691620-A1 P38 KINASE INHIBITORS REDUCE DUX4 AND DOWNSTREAM GENE EXPRESSION FOR THE TREATMENT OF FSHD Fulcrum Therapeutics, Inc. (US) 2020-08-12 — — EP disclosed
WO-2019071147-A1 P38 KINASE INHIBITORS REDUCE DUX4 AND DOWNSTREAM GENE EXPRESSION FOR THE TREATMENT OF FSHD Fulcrum Therapeutics, Inc. (US) 2019-04-11 — — WO disclosed
WO-2005018557-A2 SUBSTITUTED PYRIDINONES PHARMACIA CORPORATION (US) 2005-03-03 — — WO disclosed