Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 5/20 | 0.77 |
| ▸ | KDR | P35968 | 2/20 | 0.77 |
| ▸ | EGFR | P00533 | 1/20 | 0.77 |
| ▸ | IGF1R | P08069 | 1/20 | 0.77 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.77 |
| ▸ | SRC | P12931 | 1/20 | 0.77 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.77 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.77 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.77 |
| ▸ | CDK2 | P24941 | 1/20 | 0.77 |
| ▸ | CSK | P41240 | 1/20 | 0.77 |
| ▸ | JAK3 | P52333 | 1/20 | 0.77 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.77 |
| ▸ | AURKA | O14965 | 17/20 | 0.75 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6472492 | 0.93 | AURKB (0.78) | AURKBKDREGFRIGF1RFGFR1 | |
| SCHEMBL5048641 | 0.93 | AURKA (0.87) | AURKBKDREGFRIGF1RFGFR1 | |
| SCHEMBL5046346 | 0.90 | AURKB (0.73) | AURKBKDREGFRIGF1RFGFR1 | |
| SCHEMBL5045013 | 0.90 | AURKB (0.73) | AURKBKDREGFRIGF1RFGFR1 | |
| SCHEMBL5046348 | 0.90 | AURKB (0.73) | AURKBKDREGFRIGF1RFGFR1 | |
| SCHEMBL5045021 | 0.90 | AURKB (0.73) | AURKBKDREGFRIGF1RFGFR1 | |
| SCHEMBL6472187 | 0.89 | AURKA (0.86) | AURKBKDREGFRIGF1RFGFR1 | |
| SCHEMBL3884885 | 0.89 | AURKA (0.74) | AURKBKDREGFRIGF1RFGFR1 | |
| SCHEMBL6530607 | 0.89 | AURKA (0.74) | AURKBKDREGFRIGF1RFGFR1 | |
| SCHEMBL5048554 | 0.89 | AURKA (0.76) | AURKBKDREGFRIGF1RFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101437577-A | Combination therapy for diseases involving angiogenesis | BAUSCH & LOMB (US) | 2009-05-20 | — | — | CN | disclosed |
| EP-1575946-A1 | QUINAZOLINE COMPOUNDS | AstraZeneca AB (SE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004058752-A1 | QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-07-15 | — | — | WO | disclosed |