Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 8/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10179986 | 0.93 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1KDM4EHTR1BADRA1A | |
| SCHEMBL644884 | 0.93 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1HTR1BADRA1AADRA1D | |
| SCHEMBL644353 | 0.92 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1KDM4EALDH1A1HTR1B | |
| SCHEMBL646860 | 0.89 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL644205 | 0.88 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL646627 | 0.88 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1KDM4EALDH1A1DRD2 | |
| SCHEMBL645831 | 0.86 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1TDP1 | |
| SCHEMBL644382 | 0.86 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1 | |
| SCHEMBL644657 | 0.85 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1KDM4ESMN1; SMN2 | |
| SCHEMBL648073 | 0.85 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1KDM4EALDH1A1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2023922-B1 | TRIAZOLE DERIVATIVES II | MERCK PATENT GMBH (DE) | 2012-07-11 | — | — | EP | claimed |
| US-8119795-B2 | Triazole derivatives II | MERCK PATENT GMBH (DE) | 2012-02-21 | — | — | US | claimed |
| US-20100022540-A1 | TRIAZOLE DERIVATIVES II | MERCK PATENT GESELLSCHAFT (DE) | 2010-01-28 | — | — | US | claimed |
| EP-2023922-B1 | TRIAZOLE DERIVATIVES II | MERCK PATENT GMBH (DE) | 2012-07-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022540-A1 | TRIAZOLE DERIVATIVES II | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AA1 2/4885HSP90AB1 1/4885KDM4E 3739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.