SCHEMBL10179986

SCHEMBL10179986

CC(C)NCCOc1ccccc1CN(C)S(=O)(=O)c1cc(-c2nnc(O)n2-c2ccccc2F)c(O)cc1O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 8/20 0.47
KDM4E B2RXH2 1/20 0.36
HSP90AB1 P08238 1/20 0.33
ADRA1D P25100 3/20 0.32
ADRA1A P35348 3/20 0.32
ADRA1B P35368 3/20 0.32
SCN9A Q15858 1/20 0.31
HTR1B P28222 1/20 0.31
ADRB2 P07550 1/20 0.30
ADRB1 P08588 1/20 0.30
HTR1A P08908 1/20 0.30
ADRA2A P08913 1/20 0.30
DRD2 P14416 1/20 0.30
ADRA2B P18089 1/20 0.30
ADRA2C P18825 1/20 0.30
HTR2A P28223 1/20 0.30
HTR7 P34969 1/20 0.30
OPRM1 P35372 1/20 0.30
DRD3 P35462 1/20 0.30
HTR2B P41595 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL647283 0.93 HSP90AA1 (0.39) HSP90AA1KDM4EHSP90AB1ADRA1DADRA1A
SCHEMBL644884 0.92 HSP90AA1 (0.47) HSP90AA1HSP90AB1ADRA1DADRA1AADRA1B
SCHEMBL648073 0.92 HSP90AA1 (0.46) HSP90AA1KDM4EHSP90AB1SCN9AMAOA
SCHEMBL645400 0.89 HSP90AA1 (0.48) HSP90AA1HSP90AB1MAOAMAOBCASP3
SCHEMBL645378 0.89 HSP90AA1 (0.48) HSP90AA1HSP90AB1MAOAMAOBCASP3
SCHEMBL10179897 0.88 HSP90AA1 (0.49) HSP90AA1KDM4EHSP90AB1DRD2HTR7
SCHEMBL644635 0.86 HSP90AA1 (0.51) HSP90AA1HSP90AB1MAOAMAOBCASP3
SCHEMBL645743 0.86 HSP90AA1 (0.46) HSP90AA1HSP90AB1MAOAMAOBCASP3
SCHEMBL645488 0.85 HSP90AA1 (0.51) HSP90AA1HSP90AB1
SCHEMBL644353 0.85 HSP90AA1 (0.41) HSP90AA1KDM4EHSP90AB1ADRA1AHTR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2023922-B1 TRIAZOLE DERIVATIVES II MERCK PATENT GMBH (DE) 2012-07-11 EP claimed
EP-2023922-B1 TRIAZOLE DERIVATIVES II MERCK PATENT GMBH (DE) 2012-07-11 EP disclosed