Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.92 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.92 |
| ▸ | ESR1 | P03372 | 4/20 | 0.63 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL624311 | 1.00 | TDP1 (0.92) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Bromide SCHEMBL64728 | 1.00 | TDP1 (0.92) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Bromide SCHEMBL28046864 | 1.00 | TDP1 (0.92) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Bromide SCHEMBL3314443 | 1.00 | TDP1 (0.92) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Bromide SCHEMBL1409549 | 1.00 | TDP1 (0.92) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Bromide SCHEMBL71504 | 1.00 | TDP1 (0.92) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Bromide SCHEMBL1409552 | 1.00 | TDP1 (0.92) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Bromide SCHEMBL10792875 | 0.96 | TDP1 (0.86) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Bromide SCHEMBL1069060 | 0.96 | TDP1 (0.86) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Bromide SCHEMBL9510236 | 0.96 | TDP1 (0.86) | TDP1CYP3A4ESR1ESR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1798 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115698190-B | Light stability simulation of macular pigment | 强生视力健公司 | 2025-06-17 | — | — | CN | claimed |
| CN-118027028-A | AZ191 intermediate, preparation method and preparation method of AZ191 | 上海凌凯医药科技有限公司 | 2024-05-14 | — | — | CN | claimed |
| US-11965101-B2 | Three-dimensional dye, manufacturing method of three-dimensional dye and photoresist mixture | TCL CHINA STAR OPTOELECTRONICS TECHNOLOGY CO., LTD. (CN) | 2024-04-23 | — | — | US | claimed |
| CN-113336717-B | Process for preparing oxazolecarboxylic acid esters | 江西天新药业股份有限公司 | 2024-04-05 | — | — | CN | claimed |
| CN-112457287-B | Preparation method of E-olopatadine | 重庆西南制药二厂有限责任公司 | 2024-02-06 | — | — | CN | claimed |
| EP-4263718-A1 | PHOTOSTABLE MIMICS OF MACULAR PIGMENT | Johnson & Johnson Vision Care, Inc. (US) | 2023-10-25 | — | — | EP | claimed |
| CN-114644577-B | Environment-friendly preparation method of substituted isonitrile compound | 新发药业有限公司 | 2023-06-27 | — | — | CN | claimed |
| CN-111548369-B | Method for simply and conveniently preparing high-purity olopatadine hydrochloride intermediate | 内蒙古京东药业有限公司 | 2023-02-28 | — | — | CN | claimed |
| CN-115698190-A | Photostable simulation of macular pigment | 强生视力健公司 | 2023-02-03 | — | — | CN | claimed |
| US-20220275212-A1 | THREE-DIMENSIONAL DYE, MANUFACTURING METHOD OF THREE-DIMENSIONAL DYE AND PHOTORESIST MIXTURE | TCL CHINA STAR OPTOELECTRONICS TECHNOLOGY CO., LTD. (CN) | 2022-09-01 | — | — | US | claimed |
| US-4996178-A | Catalyst system containing organophosphorus compound and acid acceptor | THE GOODYEAR TIRE & RUBBER CO. (US) | 1991-02-26 | — | — | US | claimed |
| EP-0405436-A2 | Dihetero nitrogen-containing cycloheteroethanoanthracene derivatives as antipsychotic agents | G.D. Searle & Co. (US) | 1991-01-02 | — | — | EP | claimed |
| US-4968852-A | PHOSPHINE-RHODIUM COMPLEX DECARBONYLATION CATALYST | CENTRAL GLASS COMPANY, LIMITED (JP) | 1990-11-06 | — | — | US | claimed |
| US-4814460-A | ISOMERIZATION OF Z-ISOMER | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1989-03-21 | — | — | US | claimed |
| US-4814461-A | ISOMERIZATION OF Z-ISOMER | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1989-03-21 | — | — | US | claimed |
| EP-0092310-B1 | BIS(HALOPHENYL)HEXAFLUOROPROPANES AND PROCESS FOR MAKING THE SAME | Hughes Aircraft Company (US) | 1985-07-24 | — | — | EP | claimed |
| US-4503254-A | HALOGENATION OF HYDROXY PRECURSOR WITH TRIPHENYLPHOSPHINE DIHALIDE | HUGHES AIRCRAFT COMPANY (US) | 1985-03-05 | — | — | US | claimed |
| EP-0092310-A1 | Bis(halophenyl)hexafluoropropanes and process for making the same | Hughes Aircraft Company (US) | 1983-10-26 | — | — | EP | claimed |
| US-4301301-A | BY HYDROGENATION OF TRIPHENYLPHOSPHINE DIHALIDE IN A MONO- OR DICHLOROBENZENE SOLVENT | UBE INDUSTRIES, LTD. (JP) | 1981-11-17 | — | — | US | claimed |
| US-4079056-A | REACTING 2,4-DIAMINO-6-PTERIDINE-METHANOL-HBR WITH TRIPHENYLPHOSPHINE DIBROMIDE OR PHOSPHORUS TRIBROMIDE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) | 1978-03-14 | — | — | US | claimed |