Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7789517 | 0.95 | CA1 (0.46) | CA1CA2CA9APEX1 | |
| Hydrogen Peroxide SCHEMBL5297349 | 0.89 | — | — | |
| Bicarbonate SCHEMBL10666508 | 0.84 | CA1 (0.67) | CA1CA2CA9APEX1ACHE | |
| Bicarbonate SCHEMBL7936716 | 0.84 | — | — | |
| Hydrogen Peroxide SCHEMBL10535298 | 0.84 | — | — | |
| Hydrogen Peroxide SCHEMBL7011640 | 0.84 | — | — | |
| SCHEMBL1133571 | 0.84 | CA1 (0.62) | CA1CA2 | |
| SCHEMBL1011 | 0.84 | — | — | |
| Acetic Acid SCHEMBL28818697 | 0.82 | FFAR3 (0.58) | CA1CA2CA9FFAR3LCK | |
| Bicarbonate SCHEMBL11227999 | 0.80 | CA1 (0.60) | CA1CA2CA9APEX1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005077860-A1 | ORGANO PHOSPHATIC FERTILIZER | UNIVERSITÉ DE LAVAL (CA) | 2005-08-25 | — | — | WO | disclosed |